Brain Derived Neurotrophic Factor as a Biochemical Marker of Interest in Depression

Abstract

Depression is a complex and debilitating mental health disorder that affects millions worldwide. This dissertation investigates the multifaceted nature of depression through a comprehensive literature review, an in-depth analysis of Brain-Derived Neurotrophic Factor (BDNF), and a statistical study of demographic factors and treatment patterns. The literature review elucidates various aspects of depression, from clinical presentation to epidemiological insights and current treatment options, highlighting ongoing management challenges. Additionally, it examines the role of (BDNF) in the pathophysiology of depression, confirming its intricate link to depressive states and reinforcing its potential as a biomarker for diagnosis and therapeutic targeting. It also presents a statistical study revealing no significant associations between demographic factors and prescribed therapeutic classes for depression, suggesting the need for tailored therapeutic strategies that consider individual patient profiles. The findings highlight the critical importance of further research, and the subjectivity of currently used methods in the the diagnosis and prescription of antidepressants, which reinforces the importance of integrating biomarkers such as BDNF and adopting more personalized and effective approaches to managing depression