Résumé:
The present study investigates the subacute toxicity of combined exposure to Triclosan
and Bisphenol A in female Wistar rats. Both chemicals are well-known endocrine
disruptors, and their ubiquitous presence in consumer products raises concerns about their
health impacts. This research aimed to assess the synergistic effects of triclosan and
Bisphenol A on oxidative stress in rats. Animals were administered varying doses of the
disruptors via subcutaneous and intraperitoneal injections respectively, both individually
and in combination, for 25 days. The lowest and highest doses of Bisphenolwere 50
μg/kg/day and 100 mg/kg/day and those of triclosan were 1 mg/kg/day and 10mg/kg/day.
Another group was allowed to drink ad libitum filtered water collected from Guelma
WWTP in order to assess the effectiveness of the treatment methods of that station.
Various parameters were evaluated to understand the potential adverse consequences. The
study assessed oxidative stress biomarkers and histopathological changes in the liver,
kidneys, and ovaries. Our finding indicated significant alterations in relative organ weights,
suggesting systemic stress in all treated animals. Results demonstrated significant
physiological alterations in the organs of animals after exposure to a high dose
combination of the two chemicals and the high dose of Bisphenol A leading to disruptions
in oxidative balance. Elevated levels of AOPPs and MDA confirmed the presence of
oxidative stress.There was a notable decrease in serum glucose levels in groups treated
with low-dose mixture, indicating metabolic disruption. These changes were accompanied
by discernible hepatic and ovarian damage, confirmed through histopathological analysis.
The findings underscore the potential health risks posed by exposure to these chemicals
and advocate for heightened regulatory scrutiny and further research to mitigate human
exposure to those chemicals.
