Résumé:
: The antidiabetics gliclazide and glibenclamide are oral medications commonly
marketed for the treatment of type 2 diabetes. These molecules have low water solubility, which
leads to a reduction in their biological activity. Complexation with cyclodextrins (CDs) is one
of the most used approaches to improve the water solubility of several drugs. In this part of this
work we characterized the inclusion complexes of Gliglazide and glibenclamide: inclusion
complexes of 1:1 and 1:2 stoichiometry (host:guest) with the natural and modified CDs, βcyclodextrin (β -CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD), respectively, in solution
and solid state. The study in solution was carried out by UV-visible spectroscopy. On the other
hand, the complexes synthesized in the solid state were characterized by their melting points,
frontal ratios and IR spectroscopy. Each of these characterizations provided several elements
supporting the thesis of the formation of the complexes studied.
Key-words: Inclusion complexes; Water solubility; Biological activity; UV-visible
spectroscopy; IR spectroscopy.
