SYNTHÈSE ET CARACTÉRISATION DE NOUVELLES MOLÉCULES A EFFET BIOLOGIQUE CONTENANT DES LIGANDS SALICYLALDIMINE

Abstract

Our work is part of the synthesis and characterization of new antibacterial agents. Two compounds were synthesized, a 2-(((4-hydroxy phényle) imino) méthyl) phénol (PR1) 71.45%, and 2,2’-((1,4phenylene bis (azaneylylidene)) bis (methaneylylidene)) ( PAS) 67.46%. These synthesized compounds are identified and characterized using the usual physicochemical methods such as ultraviolet, infrared, and CCM. During the implementation of these analytical techniques, we have been able to demonstrate the structures of the synthesized compounds, while appreciating their purity. As regards the application of these compounds in the field of biology, our choice has been focused on antimicrobial and antifungal activity. The evaluation of the antibacterial effect of our compounds shows a bacterial sensitivity towards the five strains tested: Escherichia coli and, Pseudomonas aerugenosa, Klebsiella pneumoniae et Morganella morganii from Gram négative et Staphylococus aureus from gram positive. The antibacterial effect is proportional to the concentration of the compounds. The study of the antifungal activity was demonstrated by the diameter of inhibition of the Candida albicans and Candida SPP. The compounds synthesized exerted moderate activity against the fungal strain tested